EBEX: the E and B Experiment

The E and B Experiment, EBEX, is a Cosmic Microwave Background polarization experiment designed to detect or set upper limits on the signature of primordial gravity waves. Primordial gravity waves are predicted to be produced by inflation, and a measurement of the power spectrum of these gravity waves is a measurement of the energy scale of inflation. EBEX has sufficient sensitivity to detect or set an upper limit at 95% confidence on the energy scale of inflation of < 1.4 × 10^(16) GeV. This article reviews our strategy for achieving our science goals and discusses the implementation of the instrument

A high-resolution pointing system for fast scanning platforms: The EBEX example

The E and B experiment (EBEX) is a balloon-borne telescope designed to measure the polarization of the cosmic microwave background with 8' resolution employing a gondola scanning with speeds of order degree per second. In January 2013, EBEX completed 11 days of observations in a flight over Antarctica covering $\sim$ 6000 square degrees of the sky. The payload is equipped with two redundant star cameras and two sets of three orthogonal gyroscopes to reconstruct the telescope attitude. The EBEX science goals require the pointing to be reconstructed to approximately 10" in the map domain, and in-flight attitude control requires the real time pointing to be accurate to $\sim$ 0.5$^{\circ}$ . The high velocity scan strategy of EBEX coupled to its float altitude only permits the star cameras to take images at scan turnarounds, every $\sim$ 40 seconds, and thus requires the development of a pointing system with low noise gyroscopes and carefully controlled systematic errors. Here we report on the design of the pointing system and on a simulation pipeline developed to understand and minimize the effects of systematic errors. The performance of the system is evaluated using the 2012/2013 flight data, and we show that we achieve a pointing error with RMS=25" on 40 seconds azimuth throws, corresponding to an error of $\sim$ 4.6" in the map domain.Comment: 14 pages, Proceedings of the 2015 IEEE Aerospace Conferenc

Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding

Background: A significant challenge is faced for the genetic diagnosis of inherited platelet disorders in which candidate genetic variants can be found in more than 100 bleeding, thrombotic, and platelet disorder genes, especially within families in which there are both normal and low platelet counts. Genetic variants of unknown clinical significance (VUS) are found in a significant proportion of such patients in which functional studies are required to prove pathogenicity. Objective: To identify the genetic cause in patients with a suspected platelet disorder and subsequently perform a detailed functional analysis of the candidate genetic variants found. Methods: Genetic and functional studies were undertaken in three patients in two unrelated families with a suspected platelet disorder and excessive bleeding. A targeted gene panel of previously known bleeding and platelet genes was used to identify plausible genetic variants. Deep platelet phenotyping was performed using platelet spreading analysis, transmission electron microscopy, immunofluorescence, and platelet function testing using lumiaggregometry and flow cytometry. Results: We report rare conserved missense variants (p.R182C and p.A183V) in TPM4 encoding tromomyosin-4 in 3 patients. Deep platelet phenotyping studies revealed similar platelet function defects across the 3 patients including reduced platelet secretion, and aggregation and spreading defects suggesting that TPM4 missense variants impact platelet function and show a disordered pattern of tropomyosin staining. Conclusions: Genetic and functional TPM4 defects are reported making TPM4 a diagnostic grade tier 1 gene and highlights the importance of including TPM4 in diagnostic genetic screening for patients with significant bleeding and undiagnosed platelet disorders, particularly for those with a normal platelet count

Training future generations to deliver evidence-based conservation and ecosystem management

1. To be effective, the next generation of conservation practitioners and managers need to be critical thinkers with a deep understanding of how to make evidence-based decisions and of the value of evidence synthesis. 2. If, as educators, we do not make these priorities a core part of what we teach, we are failing to prepare our students to make an effective contribution to conservation practice. 3. To help overcome this problem we have created open access online teaching materials in multiple languages that are stored in Applied Ecology Resources. So far, 117 educators from 23 countries have acknowledged the importance of this and are already teaching or about to teach skills in appraising or using evidence in conservation decision-making. This includes 145 undergraduate, postgraduate or professional development courses. 4. We call for wider teaching of the tools and skills that facilitate evidence-based conservation and also suggest that providing online teaching materials in multiple languages could be beneficial for improving global understanding of other subject areas.Peer reviewe

Tropical forests and the genus Homo

Tropical forests constitute some of the most diverse and complex terrestrial ecosystems on the planet. From the Miocene onward, they have acted as a backdrop to the ongoing evolution of our closest living relatives, the great apes, and provided the cradle for the emergence of early hominins, who retained arboreal physiological adaptations at least into the Late Pliocene. There also now exists growing evidence, from the Late Pleistocene onward, for tool-assisted intensification of tropical forest occupation and resource extraction by our own species, Homo sapiens. However, between the Late Pliocene and Late Pleistocene there is an apparent gap in clear and convincing evidence for the use of tropical forests by hominins, including early members of our own genus. In discussions of Late Pliocene and Early Pleistocene hominin evolution, including the emergence and later expansion of Homo species across the globe, tropical forest adaptations tend to be eclipsed by open, savanna environments. Thus far, it is not clear whether this Early-Middle Pleistocene lacuna in Homo-rainforest interaction is real and representative of an adaptive shift with the emergence of our species or if it is simply reflective of preservation bias.For financial support, we acknowledge the Natural Environmental 314 ARTICLE Research Council (no. 1322282 to PR), the Boise Fund (to PR), the European Research Council (no. 206148 to NB, no. 617627 to JS, no. 295719 to MP), and the Leakey Foundation (to JLT)

Teaching: Making a Difference.[ 5th ed.]

When preparing pre-service teachers for their first classroom experience, academics are faced with the challenge of helping students understand what it’s really like to be a teacher. Teaching: Making a Difference, 5th Edition is a practical text that brings the classroom to life for your students. It contains all the theoretical foundations, and is supported by digital resources to demonstrate real-world applications. This market-leading text equips your students with all the tools, activities and teaching plans they need. The new fifth edition also addresses the changes in digital technology that the world has recently experienced and arms your students with the ICT competencies they’ll soon need to use in the classroom